Icotrokinra induces early and sustained pharmacodynamic responses in phase IIb study of patients with moderate-to-severe psoriasis
David Strawn, James G Krueger, Robert Bissonnette, Kilian Eyerich, Laura K Ferris, Amy S Paller, Andreas Pinter, Dylan Richards, Elizabeth Y Chen, Kate Paget, Daniel Horowitz, Roohid Parast, Joshua J Rusbuldt, Jocelyn Sendecki, Sunita Bhagat, Lynn P Tomsho, Ching-Heng Chou, Marta E Polak, Brice E Ke · 2025
Read Icotrokinra induces early and sustained pharmacodynamic responses in phase IIb study of patients with moderate-to-severe psoriasis by David Strawn, James G Krueger, Robert Bissonnette, Kilian Eyerich, Laura K Ferris, Amy S Paller, Andreas Pinter, Dylan Richards, Elizabeth Y Chen, Kate Paget, Daniel Horowitz, Roohid Parast, Joshua J Rusbuldt, Jocelyn Sendecki, Sunita Bhagat, Lynn P Tomsho, Ching-Heng Chou, Marta E Polak, Brice E Ke (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12890502.txt.
Description
David Strawn and a large team of co-authors study icotrokinra, a targeted oral peptide for moderate-to-severe psoriasis. Their 2025 paper reports early and sustained pharmacodynamic responses in a phase IIb study.
Icotrokinra is described as the first targeted oral peptide that binds the IL-23 receptor with high affinity to block IL-23 signaling precisely. In the FRONTIER-1 trial and its long-term extension, it gave high rates of complete skin clearance and durable control. This analysis looked at systemic and skin responses to the drug in trial participants. It also asked how those biological responses relate to clinical response, which can guide dosing and patient selection.
Catalog record
| CREATOR | David Strawn, James G Krueger, Robert Bissonnette, Kilian Eyerich, Laura K Ferris, Amy S Paller, Andreas Pinter, Dylan Richards, Elizabeth Y Chen, Kate Paget, Daniel Horowitz, Roohid Parast, Joshua J Rusbuldt, Jocelyn Sendecki, Sunita Bhagat, Lynn P Tomsho, Ching-Heng Chou, Marta E Polak, Brice E Ke |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |