Case report: IL12RB1 deficiency in an infant with disseminated Bacille Calmette-Guérin disease
Xiao Ma, Juping Chen, Junqiao Cheng, Jingbo Wang · 2026
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Description
Xiao Ma, Juping Chen, Junqiao Cheng, and Jingbo Wang report a vaccine reaction case in an infant in a paper published in 2025. The baby developed disseminated BCG disease, a rare spread of the tuberculosis vaccine strain, with a growing mass near the armpit three months after vaccination.
Gene tests found the cause: a defect in a receptor for interleukin-12, an inborn error of immunity that leaves children open to such infections. An expert panel confirmed the diagnosis. About twenty-eight months of combined anti-BCG drugs plus interferon-gamma brought the infection under control. The report also weighs when and for whom BCG vaccination is safest in high burden countries.
Catalog record
| CREATOR | Xiao Ma, Juping Chen, Junqiao Cheng, Jingbo Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |