ZSF1 lean rats – How healthy are they?
Antje Schauer, Beatrice Vahle, Volker Adams, Axel Linke, Antje Augstein · 2025
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Description
Antje Schauer and four co-authors asked in 2025 how healthy the lean strain of a lab rat really is. Lean rats of this strain serve as controls in studies of their obese littermates, which develop heart and metabolic disease young. Two of the lean types carry one faulty gene copy each, raising doubt about their fitness as controls. The team compared thirty-two-week-old females with standard Wistar rats.
Lean rats weighed less but had heavier hearts, kidneys, and muscles. Their hearts pumped normally, yet filling pressure and wall stiffness ran high. Blood vessel walls were stiffer, and one muscle showed weaker peak force. The authors read this as an early stage of a compliance disorder. They warn that lean controls differ from standard rats in ways studies should note.
Catalog record
| CREATOR | Antje Schauer, Beatrice Vahle, Volker Adams, Axel Linke, Antje Augstein |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |