Targeting angiogenesis in endometriosis: a systematic review and network meta-analysis of VEGF-directed pharmacotherapies
O. Hammond, O. El-Sheikh, R. M. Saad, P. Shetty, E. Papakonstantinou, S. L. Kastora · 2026
Read Targeting angiogenesis in endometriosis: a systematic review and network meta-analysis of VEGF-directed pharmacotherapies by O. Hammond, O. El-Sheikh, R. M. Saad, P. Shetty, E. Papakonstantinou, S. L. Kastora (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12883779.txt.
Description
Hammond and colleagues review drugs that target new vessel growth in endometriosis, in a paper from twenty twenty-five. Growth of new vessels, driven by one growth factor, keeps the lesions alive. Many drugs that block vessel growth have been tested, but the proof is in bits. No past work set them side by side with a focus on keeping fertility safe.
The team ran a network meta-analysis across six databases and two trial registries. Thirty-one studies of twenty-three agents qualified, from human trials to rodent work. Outcomes included lesion area and count, growth factor levels, and vessel density. Effects were ranked across the whole network on a shared scale. Checks tested match and spread in the results. Drug-gene maps probed where the drug paths meet. The aim is to rank fertility-sparing picks for tests in patients.
Catalog record
| CREATOR | O. Hammond, O. El-Sheikh, R. M. Saad, P. Shetty, E. Papakonstantinou, S. L. Kastora |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |