Characterizing molecular and behavioral changes arising from ROMK potassium channel deficiency in the cerebellum
Jacopo Agrimi, Aidan J. Dunphy, Justin C. Zhong, Wenxi Zhang, Naeem Sbaiti, Daniel R. Turner, Lucia Bernardele, D. Brian Foster, Brian O’Rourke, Nazareno Paolocci, Kyriakos N. Papanicolaou · 2026
Read Characterizing molecular and behavioral changes arising from ROMK potassium channel deficiency in the cerebellum by Jacopo Agrimi, Aidan J. Dunphy, Justin C. Zhong, Wenxi Zhang, Naeem Sbaiti, Daniel R. Turner, Lucia Bernardele, D. Brian Foster, Brian O’Rourke, Nazareno Paolocci, Kyriakos N. Papanicolaou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12883771.txt.
Description
Jacopo Agrimi and co-authors study what happens when a potassium channel is missing from the cerebellum, the brain's movement hub, in work published in two thousand twenty-five. Mice were bred to lose the channel in a set class of brain cells. The channel turned up in an unexpected cell layer of the cerebellum.
Brain cell counts stayed normal, but some cell branches grew thicker. Gene activity shifted for cerebellum-specific genes and other channel parts. Signs of cell stress also rose. The mice showed clear trouble with movement balance and more anxiety-like behavior in a maze test. The work ties the channel to circuits for complex behavior.
Catalog record
| CREATOR | Jacopo Agrimi, Aidan J. Dunphy, Justin C. Zhong, Wenxi Zhang, Naeem Sbaiti, Daniel R. Turner, Lucia Bernardele, D. Brian Foster, Brian O’Rourke, Nazareno Paolocci, Kyriakos N. Papanicolaou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |