A comparative ex vivo evaluation of colonization resistance against multidrug-resistant Enterobacterales in fecal samples from various animal species and strategies to augment it
Lisa Osbelt, Elias Eger, Timo Homeier-Bachmann, Michael Schwabe, Marie Wende, Baerbel Hammerschmidt, Andreas Vernunft, Pavaret Sivapornnukul, Meina Neumann-Schaal, Sebastian Guenther, Till Strowig, Katharina Schaufler · 2026
Read A comparative ex vivo evaluation of colonization resistance against multidrug-resistant Enterobacterales in fecal samples from various animal species and strategies to augment it by Lisa Osbelt, Elias Eger, Timo Homeier-Bachmann, Michael Schwabe, Marie Wende, Baerbel Hammerschmidt, Andreas Vernunft, Pavaret Sivapornnukul, Meina Neumann-Schaal, Sebastian Guenther, Till Strowig, Katharina Schaufler (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12883652.txt.
Description
Lisa Osbelt and co-authors compare gut resistance to drug-proof bacteria in a study published in 2025 across animal species and humans. Resistant gut bacteria spread through farms, wildlife, and people, and healthy gut communities can block them from settling. How strong that block is outside lab mice was poorly known.
Working with fecal samples in the lab, the team tested native gut communities, a probiotic candidate, and fiber additives against two resistant species. Resistance varied markedly by host group, with distinct patterns in wildlife, livestock, and humans. The probiotic reliably suppressed both invaders across sources, while the fibers helped little. Strong natural resistance tracked richer, more active gut communities.
Catalog record
| CREATOR | Lisa Osbelt, Elias Eger, Timo Homeier-Bachmann, Michael Schwabe, Marie Wende, Baerbel Hammerschmidt, Andreas Vernunft, Pavaret Sivapornnukul, Meina Neumann-Schaal, Sebastian Guenther, Till Strowig, Katharina Schaufler |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |