Recurrent CIC-rearranged sarcoma of central nervous system: a clinicopathological case report
Shan Jiang, Kay Ka-Wai Li, Jingqi Hu, Yun Guan, Rui-Ze Zhu, Hou-Shi Xu, Mao-Yuan Sun, Bei-Ning Liu, Hui-Hui Chai, Yue Wang, Qi-Sheng Tang, Ho-Keung Ng, Zhi-Feng Shi · 2026
Read Recurrent CIC-rearranged sarcoma of central nervous system: a clinicopathological case report by Shan Jiang, Kay Ka-Wai Li, Jingqi Hu, Yun Guan, Rui-Ze Zhu, Hou-Shi Xu, Mao-Yuan Sun, Bei-Ning Liu, Hui-Hui Chai, Yue Wang, Qi-Sheng Tang, Ho-Keung Ng, Zhi-Feng Shi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12883352.txt.
Description
A rare cancer called CIC-rearranged sarcoma grows from small round cells and lacks the gene change that marks its better-known cousin, Ewing sarcoma. The authors of a 2025 case report describe one such tumor in the brain, where the disease is extremely uncommon and no standard treatment exists. Diagnosis rested on a rearrangement joining the CIC gene to DUX4, confirmed with DNA methylation profiling and several other molecular methods.
The report follows the patient through combined chemotherapy and radiation, after which the tumor returned at the same site. By documenting the course in detail, the team gives clinicians one more reference point for recognizing and managing a cancer with a very poor outlook.
Catalog record
| CREATOR | Shan Jiang, Kay Ka-Wai Li, Jingqi Hu, Yun Guan, Rui-Ze Zhu, Hou-Shi Xu, Mao-Yuan Sun, Bei-Ning Liu, Hui-Hui Chai, Yue Wang, Qi-Sheng Tang, Ho-Keung Ng, Zhi-Feng Shi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 10 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |