Identification and characterization of a novel linear B-cell epitope on nucleocapsid protein of porcine epidemic diarrhea virus
Jingwen Wang, Weiqiang Zhang, Hao Lu, Chenlin Hao, Nianxiang Wang, Ziqi Wang, Erhao Zhang, Shichong Han, Lu Xia, Hui Hu · 2025
Read Identification and characterization of a novel linear B-cell epitope on nucleocapsid protein of porcine epidemic diarrhea virus by Jingwen Wang, Weiqiang Zhang, Hao Lu, Chenlin Hao, Nianxiang Wang, Ziqi Wang, Erhao Zhang, Shichong Han, Lu Xia, Hui Hu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12882500.txt.
Description
Jingwen Wang and co-authors pinpoint a tiny stretch of a pig virus protein that antibodies grip, in a 2025 paper. The virus causes deadly diarrhoea in newborn piglets, and no good vaccine or cure exists, so fast, exact diagnosis carries the fight. Its nucleocapsid protein is stable and strongly provokes antibodies, making it the favourite target for blood tests. The team set out to map exactly where antibodies land on it.
They produced the protein in the lab and raised three custom antibodies against it. All three belonged to the same antibody class and hit this virus only, ignoring two close cousins. Testing chopped-up pieces of the protein showed one antibody locks onto a nine-letter stretch never described before. Comparing that stretch across virus strains helps judge whether a future test would catch them all.
Catalog record
| CREATOR | Jingwen Wang, Weiqiang Zhang, Hao Lu, Chenlin Hao, Nianxiang Wang, Ziqi Wang, Erhao Zhang, Shichong Han, Lu Xia, Hui Hu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |