Use of lorazepam for analgosedation during mechanical ventilation in pediatric intensive care
Paul Healy, Marco Marano, Marcello Montibeller, Bianca Maria Goffredo, Giuseppe Pontrelli, Oscar Della Pasqua · 2026
Read Use of lorazepam for analgosedation during mechanical ventilation in pediatric intensive care by Paul Healy, Marco Marano, Marcello Montibeller, Bianca Maria Goffredo, Giuseppe Pontrelli, Oscar Della Pasqua (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12879046.txt.
Description
Six researchers model lorazepam dosing for sedated children on ventilators in a paper whose text is dated 2025. The drug is used off label in pediatric intensive care as a stand in for the standard sedative. Its mid length action suits steady sedation, yet dosing proof in children is thin.
The team started from a pilot of six young children with drug levels and comfort scores. A population model that accounts for growth and maturation fit those data. Simulations in a virtual cohort of one hundred children then tested dosing plans over three days. The work sets target levels and sketches the size and timing a real trial would need.
Catalog record
| CREATOR | Paul Healy, Marco Marano, Marcello Montibeller, Bianca Maria Goffredo, Giuseppe Pontrelli, Oscar Della Pasqua |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |