Molecular insights in HIV-associated cardiac dysfunction
María Valero-Muñoz, Eng Leng Saw, David R. Pimentel, Adam C. Gower, Suman Srinivasa, Markella V. Zanni, Mabel Toribio, Steven K. Grinspoon, Flora Sam · 2025
Read Molecular insights in HIV-associated cardiac dysfunction by María Valero-Muñoz, Eng Leng Saw, David R. Pimentel, Adam C. Gower, Suman Srinivasa, Markella V. Zanni, Mabel Toribio, Steven K. Grinspoon, Flora Sam (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12877094.txt.
Description
María Valero-Muñoz and eight co-authors probe how HIV and its drugs each mark the heart's muscle cells. People with HIV now live long on drug care, yet heart disease tops their causes of death. Their 2025 study bathes rat heart cells in serum from ten patients, taken before drug care and six months in.
Serum from the untreated phase killed more heart cells. Serum from the treated phase shifted calcium gear and woke scar and matrix genes. Those shifts point to stiff, poorly relaxing hearts. The pattern says virus and drugs play unlike parts in the harm. Both push toward the stiff-heart failure that stalks this group. The work names paths for guard drugs to test.
Catalog record
| CREATOR | María Valero-Muñoz, Eng Leng Saw, David R. Pimentel, Adam C. Gower, Suman Srinivasa, Markella V. Zanni, Mabel Toribio, Steven K. Grinspoon, Flora Sam |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |