Memantine and graded motor imagery for complex regional pain syndrome (MEMOIR): study protocol and statistical analysis plan for a decentralised, 2 × 2 factorial randomised trial
Michael C Ferraro, Yannick L Gilanyi, Eric J Visser, Andrew J McLachlan, G Lorimer Moseley, Benedict M Wand, Neil E O’Connell, Hopin Lee, Martin Lotze, Jody Church, Stephen Goodall, Robert D Herbert, Sarah E Lamb, Sylvia M Gustin, Aidan G Cashin, James H McAuley · 2025
Read Memantine and graded motor imagery for complex regional pain syndrome (MEMOIR): study protocol and statistical analysis plan for a decentralised, 2 × 2 factorial randomised trial by Michael C Ferraro, Yannick L Gilanyi, Eric J Visser, Andrew J McLachlan, G Lorimer Moseley, Benedict M Wand, Neil E O’Connell, Hopin Lee, Martin Lotze, Jody Church, Stephen Goodall, Robert D Herbert, Sarah E Lamb, Sylvia M Gustin, Aidan G Cashin, James H McAuley (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12874714.txt.
Description
Michael Ferraro and a large team publish the plan for a pain trial in this two thousand twenty-five protocol paper. The condition is complex regional pain syndrome, a rare disorder with severe limb pain and odd sensory and motor signs. Proven treatments are scarce. Two candidates show early promise: a drug called memantine and a rehab method called graded motor imagery. The MEMOIR trial will test both at once.
The design is a two-by-two factorial trial run fully at a distance. Patients are assigned to drug or placebo, and to the rehab method or a control. This layout can judge each treatment and their combination. The paper also fixes the statistical plan in advance. Clear plans guard against bias in reading the results.
Catalog record
| CREATOR | Michael C Ferraro, Yannick L Gilanyi, Eric J Visser, Andrew J McLachlan, G Lorimer Moseley, Benedict M Wand, Neil E O’Connell, Hopin Lee, Martin Lotze, Jody Church, Stephen Goodall, Robert D Herbert, Sarah E Lamb, Sylvia M Gustin, Aidan G Cashin, James H McAuley |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |