Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma
Yunzhan Li, Zekun Li, Qin Li, Dongxiao Sun, Bo Ni, Mingjun Tan, Ashley E Shay, Min Wang, Chenyang Meng, Guangcong Shen, Boyang Fu, Yueying Shan, Shiqi Zhang, Rifah Rownak Tanshee, Tianxing Zhou, Yongjie Xie, Kun-Ming Chen, Bin Qiao, Yunkun Dang, Scot R Kimball, Guanshi Zhang, Girish H Rajacharya, Pa · 2025
Read Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma by Yunzhan Li, Zekun Li, Qin Li, Dongxiao Sun, Bo Ni, Mingjun Tan, Ashley E Shay, Min Wang, Chenyang Meng, Guangcong Shen, Boyang Fu, Yueying Shan, Shiqi Zhang, Rifah Rownak Tanshee, Tianxing Zhou, Yongjie Xie, Kun-Ming Chen, Bin Qiao, Yunkun Dang, Scot R Kimball, Guanshi Zhang, Girish H Rajacharya, Pa (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12872613.txt.
Description
Yunzhan Li and co-authors expose a weakness of pancreatic cancer in a 2025 study. The tumor's surroundings starve it of cystine, an amino acid vital for defense against oxidative damage. Cells that adapt to that starvation, the team finds, grow faster by boosting a side route of sugar metabolism.
That route feeds building blocks for DNA and fats, while fat storage droplets shield the cells from fat toxicity. A drug screen spots an existing drug that blocks fat assembly, slowing adapted tumors and boosting chemotherapy. The authors present the fat pathway as a targetable flaw created by the tumor's own adaptation.
Catalog record
| CREATOR | Yunzhan Li, Zekun Li, Qin Li, Dongxiao Sun, Bo Ni, Mingjun Tan, Ashley E Shay, Min Wang, Chenyang Meng, Guangcong Shen, Boyang Fu, Yueying Shan, Shiqi Zhang, Rifah Rownak Tanshee, Tianxing Zhou, Yongjie Xie, Kun-Ming Chen, Bin Qiao, Yunkun Dang, Scot R Kimball, Guanshi Zhang, Girish H Rajacharya, Pa |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 108 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |