Mechanism of exercise-derived circulating exosomes as a target for sarcopenia management
Xiangbo Wang, Hui Huang, Jie Chen, Qing Zhang, Zhichao Yuan, Mingyue Yin, Chenggen Peng, Songlin Liu · 2026
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Description
Xiangbo Wang and seven colleagues review how exosomes shed in blood during exercise could be targeted to manage sarcopenia, in a paper from twenty twenty-five. Sarcopenia is the loss of muscle mass and function that comes with age. Its roots span protein imbalance, failing cell power plants, chronic inflammation, and weak muscle stem cells. Exosomes released during exercise carry messages between cells.
The review sums up how these exosomes form and are secreted during exercise. Mechanical, calcium, metabolic, and hormone signals all regulate their release. Their cargo then acts across the body on muscle repair. Key paths include a guard against fat toxicity and protein balance kept by a specific microRNA. A further path calms inflammation through shifts in guard cells. The authors discuss how exosomes could become therapy targets. They close with future steps for exercise-based muscle protection.
Catalog record
| CREATOR | Xiangbo Wang, Hui Huang, Jie Chen, Qing Zhang, Zhichao Yuan, Mingyue Yin, Chenggen Peng, Songlin Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |