Dinutuximab beta versus historical controls in the treatment of relapsed neuroblastoma: unadjusted and adjusted indirect comparisons
Holger N. Lode, Przemysław Holko, Aleksandra Wieczorek, Katarzyna Śladowska, Nikolai Siebert, Dominique Valteau-Couanet, Alberto Garaventa, Adela Cañete, John Anderson, Isaac Yaniv, Shifra Ash, Lucas Moreno, Juliet Gray, Roberto Luksch, Genevieve Laureys, Cormac Owens, Carla Manzitti, Sascha Troschk · 2026
Read Dinutuximab beta versus historical controls in the treatment of relapsed neuroblastoma: unadjusted and adjusted indirect comparisons by Holger N. Lode, Przemysław Holko, Aleksandra Wieczorek, Katarzyna Śladowska, Nikolai Siebert, Dominique Valteau-Couanet, Alberto Garaventa, Adela Cañete, John Anderson, Isaac Yaniv, Shifra Ash, Lucas Moreno, Juliet Gray, Roberto Luksch, Genevieve Laureys, Cormac Owens, Carla Manzitti, Sascha Troschk (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12872524.txt.
Description
Holger Lode and co-authors compare an antibody therapy, dinutuximab beta, with historical controls in relapsed neuroblastoma, in work the head dates to 2025. The therapy is used as maintenance for this childhood cancer when it returns or resists care. Direct comparisons with no such therapy are lacking.
Three studies of the therapy with individual patient data are set against two historical control cohorts. Both simple and population-adjusted comparisons of overall survival are made, using weighting methods. Harmonized entry rules are applied across cohorts. The indirect design estimates benefit where a head-to-head trial is absent.
Catalog record
| CREATOR | Holger N. Lode, Przemysław Holko, Aleksandra Wieczorek, Katarzyna Śladowska, Nikolai Siebert, Dominique Valteau-Couanet, Alberto Garaventa, Adela Cañete, John Anderson, Isaac Yaniv, Shifra Ash, Lucas Moreno, Juliet Gray, Roberto Luksch, Genevieve Laureys, Cormac Owens, Carla Manzitti, Sascha Troschk |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |