K+ channel blockade limits AF and suppresses phase 3 EADs by slowing repolarization in an electromechanical cell computational model
Fazeelat Mazhar, Stefano Severi, Chiara Bartolucci · 2026
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Description
Fazeelat Mazhar, Stefano Severi, and Chiara Bartolucci model how blocking certain potassium channels affects an irregular heart rhythm, in a research paper from 2025. The rhythm, atrial fibrillation, affects the upper heart chambers. Blocking channels found mostly in those chambers could calm it with fewer side effects elsewhere.
Using a computer model that couples electrical and mechanical action in a heart cell, the team tested two blocking drugs. Blocking slowed the cell's reset phase, which suppressed one kind of faulty extra beat. It also removed a calcium overload that drives another kind. But in some settings it raised the risk of a different early beat. The authors weigh these mixed effects.
Catalog record
| CREATOR | Fazeelat Mazhar, Stefano Severi, Chiara Bartolucci |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |