Sevoflurane attenuates hypoxia/reoxygenation-induced cardiomyocyte injury via the LncRNA FAM201A/miR-488-3p/PTEN axis
Chen Yang, Yuanzhi Li, Qiang Li, Xibao Shi, Jinping Li, Ying Chen, Huiling Qin · 2025
Read Sevoflurane attenuates hypoxia/reoxygenation-induced cardiomyocyte injury via the LncRNA FAM201A/miR-488-3p/PTEN axis by Chen Yang, Yuanzhi Li, Qiang Li, Xibao Shi, Jinping Li, Ying Chen, Huiling Qin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12870448.txt.
Description
Chen Yang and co-authors trace in 2025 how an anesthetic gas shields heart cells from the harm of restored blood flow. When a blocked heart artery reopens, the returning oxygen can itself injure muscle. The gas sevoflurane, given ahead, softens that blow, but the molecular route was murky.
In lab heart cells starved of oxygen then refed, a long non-coding RNA rose sharply and the gas pushed it back down. Forcing that RNA high erased the gas's protection, raising cell death, stress, and swelling marks. The RNA works by trapping a small partner RNA, which frees a target gene. Blocking the long RNA restored the shield.
Catalog record
| CREATOR | Chen Yang, Yuanzhi Li, Qiang Li, Xibao Shi, Jinping Li, Ying Chen, Huiling Qin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |