Multi-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis
Liao Peng, Jia-wei Chen, Yuan-zhuo Chen, Xing-peng Di, Le-de Lin, Bo-ya Li, Chi Zhang, Wei Wang, Xiao-shuai Gao, Yu-cheng Ma, Si-hong Shen, Hai-rui Li, Xiao-fang Xu, Xiao Zeng, Hong Shen, Qun Sun, Tao Jin, De-yi Luo · 2025
Read Multi-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis by Liao Peng, Jia-wei Chen, Yuan-zhuo Chen, Xing-peng Di, Le-de Lin, Bo-ya Li, Chi Zhang, Wei Wang, Xiao-shuai Gao, Yu-cheng Ma, Si-hong Shen, Hai-rui Li, Xiao-fang Xu, Xiao Zeng, Hong Shen, Qun Sun, Tao Jin, De-yi Luo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12868900.txt.
Description
Liao Peng and a large team of co-authors published a 2025 multi-omics study tracing bladder injury in interstitial cystitis to a chain that starts in the gut. This painful bladder condition has no clear upstream cause. The team combined microbe sequencing, chemical profiling of urine and blood, and single cell gene data to hunt for one.
One gut microbe stood out as enriched, alongside a marked shift in bile acids, with one acid sharply raised. Single cell data showed both changes converge on a receptor, TLR3, in the bladder lining cells. Lab tests confirmed the chain: the microbe and the bile acid together broke the bladder barrier and fired inflammation. Blocking the receptor eased the injury in models.
Catalog record
| CREATOR | Liao Peng, Jia-wei Chen, Yuan-zhuo Chen, Xing-peng Di, Le-de Lin, Bo-ya Li, Chi Zhang, Wei Wang, Xiao-shuai Gao, Yu-cheng Ma, Si-hong Shen, Hai-rui Li, Xiao-fang Xu, Xiao Zeng, Hong Shen, Qun Sun, Tao Jin, De-yi Luo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |