Rapid endothelialization of printed vascular grafts by perivascular niche-circulating endothelial progenitors crosstalk
Zhe-qian Zhang, Ping-Ping Yuan, Cong Yao, Yu-xin Lu, Yi-dong Hu, Zhen-nan Qiu, Wen-yu Zhan, Xin-chi Zhang, Yu-jiao Wang, Xiao-peng Wu, Ya-jing Zhao, Peng-yu Wang, Ning Leng, Cun Zhang, Jian-kang He, Wei Wu · 2025
Read Rapid endothelialization of printed vascular grafts by perivascular niche-circulating endothelial progenitors crosstalk by Zhe-qian Zhang, Ping-Ping Yuan, Cong Yao, Yu-xin Lu, Yi-dong Hu, Zhen-nan Qiu, Wen-yu Zhan, Xin-chi Zhang, Yu-jiao Wang, Xiao-peng Wu, Ya-jing Zhao, Peng-yu Wang, Ning Leng, Cun Zhang, Jian-kang He, Wei Wu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12868887.txt.
Description
Zhe-qian Zhang and co-authors show how printed small blood vessel grafts can gain a living lining within two weeks. Their 2025 study solves a known failure point: narrow grafts clog unless their inner surface quickly grows endothelium, the slick cell layer of natural vessels. The team printed grafts with a micro-nano structure and a very porous wall, then implanted them in rabbits.
The outer coat of the vessel grew fast into the porous wall, and that growth drew in circulating progenitor cells that lined the inner surface. Nine of ten grafts stayed open, and the rebuilt vessels matched natural ones in build and function. Lymph vessel cells in the new outer coat appear to drive the crosstalk.
Catalog record
| CREATOR | Zhe-qian Zhang, Ping-Ping Yuan, Cong Yao, Yu-xin Lu, Yi-dong Hu, Zhen-nan Qiu, Wen-yu Zhan, Xin-chi Zhang, Yu-jiao Wang, Xiao-peng Wu, Ya-jing Zhao, Peng-yu Wang, Ning Leng, Cun Zhang, Jian-kang He, Wei Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 93 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |