Propofol-related biological alterations and incidence of propofol infusion syndrome in status epilepticus: a 10-year cohort study
Chanez Djahel, Clémence Marois, Léa Cosme, Zineb Hayatou, Nesrine Braham Ghedira, Quentin Calonge, Vincent Navarro, Adam Celier, Dominique Bonnefont-Rousselot, Randa Bittar, Sophie Demeret, Aurélie Hanin · 2026
Read Propofol-related biological alterations and incidence of propofol infusion syndrome in status epilepticus: a 10-year cohort study by Chanez Djahel, Clémence Marois, Léa Cosme, Zineb Hayatou, Nesrine Braham Ghedira, Quentin Calonge, Vincent Navarro, Adam Celier, Dominique Bonnefont-Rousselot, Randa Bittar, Sophie Demeret, Aurélie Hanin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12867868.txt.
Description
Chanez Djahel and eleven co-authors spend ten years of intensive care data asking what propofol does to the rest of the body. Propofol is the anesthetic holding seizures down. In refractory status epilepticus it can be lifesaving, yet its shadow is a list of harms crowned by propofol infusion syndrome, a rare, often fatal collapse. Their study was published in 2025.
The cohort is 235 patients admitted to the Pitié-Salpêtrière neurointensive unit in Paris for at least 48 hours between 2015 and 2024. Twenty blood markers spanning acid-base balance, organ function, fat metabolism, and inflammation were tracked. Because effects lag, each day's labs were judged against the previous day's propofol exposure, in mixed models that compare patients with their own baselines and the unexposed. A second aim counts how often the dreaded syndrome actually occurred at this referral center.
Catalog record
| CREATOR | Chanez Djahel, Clémence Marois, Léa Cosme, Zineb Hayatou, Nesrine Braham Ghedira, Quentin Calonge, Vincent Navarro, Adam Celier, Dominique Bonnefont-Rousselot, Randa Bittar, Sophie Demeret, Aurélie Hanin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |