Construction and characterization of the ORF131 gene deletion strain of lumpy skin disease virus
Jiaqi Li, Weitao Huang, Qunhua Ke, Miaomiao Li, Xiangwei Wang, Qi Wang, Xiangping Yin, Yuefeng Sun · 2025
Read Construction and characterization of the ORF131 gene deletion strain of lumpy skin disease virus by Jiaqi Li, Weitao Huang, Qunhua Ke, Miaomiao Li, Xiangwei Wang, Qi Wang, Xiangping Yin, Yuefeng Sun (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12866479.txt.
Description
Jiaqi Li and co-authors build a gene-deleted strain of lumpy skin disease virus in a 2025 study. The cattle disease is reportable worldwide and costs the industry heavily. Live vaccines exist, but safer gene-deleted versions are still wanted.
The team removed one gene of unclear function and tagged the virus with a glow marker. Lab checks confirmed a pure strain free of the wild virus. The strain stayed genetically stable, with best harvest at three days in kidney cells. Infected cells showed stronger immune and inflammatory responses than wild virus caused. The authors offer the strain as a vaccine candidate and a base for control research.
Catalog record
| CREATOR | Jiaqi Li, Weitao Huang, Qunhua Ke, Miaomiao Li, Xiangwei Wang, Qi Wang, Xiangping Yin, Yuefeng Sun |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |