Cardiomyocyte overexpression of microRNA-210 mitigates apoptotic cell death induced by doxorubicin
Johan Guthormsen, Mikal Solstad Øiaas, Mido Magdi Allam, Gurdeep Marwarha, Morten Andre Høydal · 2025
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Description
A strong cancer drug, doxorubicin, can damage the heart even as it saves lives. Johan Guthormsen and co-authors tested a tiny RNA that might shield heart cells from that drug in this 2025 study. The RNA, called miR-210, had already shown heart-protective effects in low-oxygen heart disease. Whether it guards against drug damage was open.
The team raised or lowered the RNA in lab-grown heart cells, then dosed the cells with the drug for a day. Cell death was read by a leakage test, and programmed cell death was checked apart. The title gives the finding: more of the RNA meant less programmed death under the drug. A shield like this, if it holds in animals, could widen the safe use of a key cancer drug.
Catalog record
| CREATOR | Johan Guthormsen, Mikal Solstad Øiaas, Mido Magdi Allam, Gurdeep Marwarha, Morten Andre Høydal |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |