The functional mechanism and clinical significance of miR-3651 in the healing process of Pilon fractures
Shuang Liang, Zhijian Sun, Tenglong Dai, Xiangyu Cao, Boxuan Huang, Yuqing Wang, Ruixuan Wang, Jun Wu · 2025
Read The functional mechanism and clinical significance of miR-3651 in the healing process of Pilon fractures by Shuang Liang, Zhijian Sun, Tenglong Dai, Xiangyu Cao, Boxuan Huang, Yuqing Wang, Ruixuan Wang, Jun Wu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12866041.txt.
Description
Shuang Liang and co-authors study a small RNA in bone fracture healing in a 2025 paper. Pilon fractures are severe ankle injuries that often heal slowly. The RNA, called miR-3651, was little understood in this setting.
The team measured miR-3651 and its target gene KRAS in patient samples. Levels of the RNA ran high in the slow-healing group, while KRAS ran low. The RNA separated slow from normal healing well and counted as a risk factor. Blocking it in cells cut bone-eating cell activity and aided bone-forming cells. A reporter test confirmed the RNA targets KRAS directly.
Catalog record
| CREATOR | Shuang Liang, Zhijian Sun, Tenglong Dai, Xiangyu Cao, Boxuan Huang, Yuqing Wang, Ruixuan Wang, Jun Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |