Mitochondrial fission and fusion in inflammatory diseases: mechanisms and therapeutic implications
Wenjing Xu, Xinru Xu, Yaonan Zhang, Fenfen Li, Daozong Xia · 2025
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Description
Wenjing Xu and co-authors review how the splitting and joining of mitochondria feed inflammation, in a 2025 paper. Mitochondria are the cell's power plants, and they constantly merge and divide. A set of named proteins steers that balance and keeps the cell in order.
When the balance tips, the power plants leak reactive waste and bits of their own DNA. Immune cells then switch states and fire up inflammation paths. The review gathers ways to push the balance back, from small drugs and plant compounds to gene work and targeted nano carriers. The authors see promise in the approach, while noting hard steps before clinic use.
Catalog record
| CREATOR | Wenjing Xu, Xinru Xu, Yaonan Zhang, Fenfen Li, Daozong Xia |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |