Transcription factor NRF2 and the expression of the Hippo pathway effector TAZ in bladder tumorigenesis are significantly correlated
Mohammad Vahabirad, Hadi Ghasemi, Atefeh Pegah, Zahra Goli, Heidar Tavilani · 2025
Read Transcription factor NRF2 and the expression of the Hippo pathway effector TAZ in bladder tumorigenesis are significantly correlated by Mohammad Vahabirad, Hadi Ghasemi, Atefeh Pegah, Zahra Goli, Heidar Tavilani (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12864572.txt.
Description
Mohammad Vahabirad and four co-authors study two gene switches in bladder cancer in this 2025 paper. One switch, called NRF2, helps cells handle chemical stress from oxidation. The other, called TAZ, helps control gene activity and is tied to tumor growth. The team asked how the two relate in patients.
The study compared thirty-five bladder cancer patients with thirty-five healthy people. Both gene switches were far more active in tumor tissue than in healthy tissue. Higher activity also tracked with higher tumor grade, and the two switches rose together. Patients showed more oxidation load and less defense against it than the healthy group. The authors link the pair to both tumor growth and cell stress.
Catalog record
| CREATOR | Mohammad Vahabirad, Hadi Ghasemi, Atefeh Pegah, Zahra Goli, Heidar Tavilani |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |