Assessment of quality control and effect of radiolysis on the in vivo biodistribution of [177Lu]Lu-PSMA-I&T
Eline L. Hooijman, Carolline M. Ntihabose, Stijn L. W. Koolen, Maryana Handula, Savanne Beekman, Debra Stuurman, Corrina de Ridder, Jan R. de Jong, Jordy R. J. P. van de Merbel, Nyah Rook, Else A. Aalbersberg, Tessa F. F. T. Ververs, Peter Laverman, Jeroen J. M. A. Hendrikx, Erik de Blois · 2025
Read Assessment of quality control and effect of radiolysis on the in vivo biodistribution of [177Lu]Lu-PSMA-I&T by Eline L. Hooijman, Carolline M. Ntihabose, Stijn L. W. Koolen, Maryana Handula, Savanne Beekman, Debra Stuurman, Corrina de Ridder, Jan R. de Jong, Jordy R. J. P. van de Merbel, Nyah Rook, Else A. Aalbersberg, Tessa F. F. T. Ververs, Peter Laverman, Jeroen J. M. A. Hendrikx, Erik de Blois (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12864547.txt.
Description
Eline Hooijman and colleagues check whether labs worldwide can spot decay in a radioactive prostate cancer drug, and what that decay does in the body, in this study from twenty twenty-five. The drug carries lutetium-177 to PSMA on tumor cells. Its own radiation slowly chews it up, a process called radiolysis, and broken drug may wander off target.
Hospitals compared their liquid chromatography methods and could each measure the damage consistently, with only small spread between labs. One official method separated peaks better but lost more sample, with no gain in the purity verdict. In mice bearing prostate tumors, batches made at three purity levels behaved as feared: the more degraded the drug, the less it favored tumor over kidney. The authors say quality control for radiolysis is trustworthy across sites, and worth keeping tight.
Catalog record
| CREATOR | Eline L. Hooijman, Carolline M. Ntihabose, Stijn L. W. Koolen, Maryana Handula, Savanne Beekman, Debra Stuurman, Corrina de Ridder, Jan R. de Jong, Jordy R. J. P. van de Merbel, Nyah Rook, Else A. Aalbersberg, Tessa F. F. T. Ververs, Peter Laverman, Jeroen J. M. A. Hendrikx, Erik de Blois |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |