Feasibility of albumin binding modulation in FAP-targeting radiopharmaceuticals: insights from molecular docking and experimental analysis
Sudabeh Shokrollahi, Ahmad Amiri · 2025
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Description
Sudabeh Shokrollahi and Ahmad Amiri study how two tumor-targeting radioactive drugs cling to albumin, the blood's main carrier protein. Their study appeared in 2025. Both drugs aim at a protein common on cancer support tissue. Computer docking gave moderate binding strengths for the pair, which matched their short stay in blood measured in animals. Cousin molecules built to grip albumin harder docked stronger and stayed longer, as designed.
Bench tests, fluorescence dimming, shape-sensitive spectra, and electrochemistry, confirmed the drugs do bind and slightly reshape the protein. The authors say the albumin grip is a dial designers can turn: stronger binding buys circulation time, which next-generation versions can spend on reaching tumors.
Catalog record
| CREATOR | Sudabeh Shokrollahi, Ahmad Amiri |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |