From maternal microbes to offspring development: gut microbiota-derived thiamine regulates the gut microbiota and drives the placental Notch pathway to coordinate angiogenesis and nutrient transport
Guodong Sun, Ze Wang, Xing Guo, Haoyang Sun, Teng Teng, Baoming Shi · 2025
Read From maternal microbes to offspring development: gut microbiota-derived thiamine regulates the gut microbiota and drives the placental Notch pathway to coordinate angiogenesis and nutrient transport by Guodong Sun, Ze Wang, Xing Guo, Haoyang Sun, Teng Teng, Baoming Shi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12860190.txt.
Description
Guodong Sun and co-authors studied how maternal gut microbes shape offspring development through thiamine, working with sows of differing breeding potential. A mother's microbes influence her body balance through metabolites. Placental blood flow and nutrient transport decide fetal growth outcomes, but which microbial products drive reproductive success was unclear.
Profiling of metabolites and fecal sequencing compared high and low-rated sows. High performers showed raised blood arginine and fecal thiamine, and a Lactococcus group was enriched in their feces as well. Thiamine was then tested as the key metabolite, and follow-up work traced how it supports placental function. The study links a vitamin made in the gut to litter success. Pig breeding and the feeding of mothers may both benefit.
Catalog record
| CREATOR | Guodong Sun, Ze Wang, Xing Guo, Haoyang Sun, Teng Teng, Baoming Shi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |