Bridging iron and lung injury: the emerging role of ferroptosis in ARDS

Yuanjun Zhang, Ji Luo, Zhiqiang Tang, Hui Gao · 2025

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Description

Yuanjun Zhang and co-authors review the role of an iron-driven cell death in acute lung failure, in this 2025 paper. The syndrome floods and stiffens the lungs after many kinds of insult, and no drug yet strikes its core. The death route, ferroptosis, runs on iron and fat damage.

The review lays out how the route works and where it shows up in each cause of the syndrome. Links run both ways: the death route worsens barrier leaks, and lung damage feeds it. Drugs that block the route get a full hearing, as do the field's open fights. The authors map gaps for the next wave of work.

Catalog record

CREATORYuanjun Zhang, Ji Luo, Zhiqiang Tang, Hui Gao
YEAR2025
COLLECTIONPAPERS
FORMATTXT
FILE SIZE37 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC12860068

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