Role of Trichostatin A (TSA) in modulating the epigenetic modification in the lymphocytes of colorectal cancer (CRC)
R. Ilaya Kumar, Kavya Jain, Harshnna Gururajan, Karan Raj Rai, Melvin George, Koustav Sarkar · 2025
Read Role of Trichostatin A (TSA) in modulating the epigenetic modification in the lymphocytes of colorectal cancer (CRC) by R. Ilaya Kumar, Kavya Jain, Harshnna Gururajan, Karan Raj Rai, Melvin George, Koustav Sarkar (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12860036.txt.
Description
Ilaya Kumar and five co-authors test a chemical tool on immune cells from colorectal cancer patients in this 2025 study. The tool, trichostatin A, can rewrite the chemical tags that control which genes are active. The team asked whether a low dose, applied briefly, could retune patients' lymphocytes toward attacking tumors rather than calming down.
Cells from patients and healthy donors were treated for twelve hours and then profiled. Treated patient cells made more attack signals and fewer calming ones, and the gene pattern shifted the same way. Chemical tags on the proteins that package DNA also moved toward a more open, active state. The treated lymphocytes killed more cancer cells in a dish, though their internal chemistry showed strain. The authors propose the drug as a gentle add-on for immune therapy and call for animal and clinical follow-up.
Catalog record
| CREATOR | R. Ilaya Kumar, Kavya Jain, Harshnna Gururajan, Karan Raj Rai, Melvin George, Koustav Sarkar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |