Comparison of the effective dose of alfentanil for percutaneous thermal ablation in subcapsular versus non-subcapsular hepatocellular carcinoma: a prospective dose-finding study utilizing the up-and-down sequential allocation method
Siqun Xiao, Die Qiu, Wen Zhang, Shunv Cai · 2025
Read Comparison of the effective dose of alfentanil for percutaneous thermal ablation in subcapsular versus non-subcapsular hepatocellular carcinoma: a prospective dose-finding study utilizing the up-and-down sequential allocation method by Siqun Xiao, Die Qiu, Wen Zhang, Shunv Cai (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12860031.txt.
Description
Siqun Xiao, Die Qiu, Wen Zhang, and Shunv Cai run a dose-finding study for pain control during a liver tumor procedure in a 2025 paper. The procedure burns tumors through the skin with heat. Tumors near the liver's surface hurt more during burning, so the team asked how much of the pain drug alfentanil each group needs.
Sixty patients were split by how close the tumor sat to the liver capsule. Doses rose or fell step by step based on the prior patient's response, a method called up-and-down allocation. The dose that worked for half the patients was clearly higher for surface tumors. The authors say teams should plan stronger pain control for those cases.
Catalog record
| CREATOR | Siqun Xiao, Die Qiu, Wen Zhang, Shunv Cai |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |