The clinical significance of miR-18a-3p in traumatic spinal cord injury and its functional role in mediating apoptosis, inflammation and oxidative stress
Yingnan Li, Bin Dai, Zhijian Cheng, Meini Cen · 2025
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Description
Li, Dai, Cheng, and Cen study a small RNA called miR-18a-3p in traumatic spinal cord injury in a 2025 paper. Such RNAs help steer cell processes after injury. The team tested the RNA as a blood marker and probed its role in cells.
Blood levels differed across patients with no injury, partial injury, and complete injury. The marker sorted these groups well and tracked with inflammation levels. A gene called DLST was confirmed as its target. In nerve-like cells under inflammatory stress, blocking the RNA raised survival and lowered cell death, inflammation, and oxidative harm. Silencing the target gene undid those gains. The authors propose the RNA as a marker and target.
Catalog record
| CREATOR | Yingnan Li, Bin Dai, Zhijian Cheng, Meini Cen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |