TAGLN: a stiffness-driven prognostic biomarker for metastatic colorectal cancer
Yanshuo Ye, Yiyang Jia, Wei Li · 2025
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Description
Yanshuo Ye, Yiyang Jia, and Wei Li identify a stiffness-driven gene marking metastatic colorectal cancer. Their study from twenty twenty-five names the gene TAGLN. Stiff tumour surroundings push cancer cells toward spread. Public cancer data first linked high TAGLN to poor survival.
Lab work showed extra TAGLN speeds identity change and migration. Gene profiles tied it to matrix rebuilding and cell adhesion. Stiff artificial matrices switched the gene on in cells. Its levels rose from normal tissue to tumours to metastases. Related cross-linking and transition mediators moved with it. TAGLN may serve as both warning marker and drug target. Mechanical forces join genes in explaining metastasis here.
Catalog record
| CREATOR | Yanshuo Ye, Yiyang Jia, Wei Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |