Dynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasis
Rundong Jiang, Joseph Kirma, Jennifer Fox, Xianying Xing, Jiaqi Wang, Mrinal K. Sarkar, Rachael Bogle, Tran Do, Anthony Coon, Christopher Cole, Olesya Plazyo, Joanna E. Rew, Haihan Zhang, J. Michelle Kahlenberg, Allison C. Billi, Hervé Bachelez, Lam C. Tsoi, Paul W. Harms, Shuai Shao, Xiang Chen, Jo · 2025
Read Dynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasis by Rundong Jiang, Joseph Kirma, Jennifer Fox, Xianying Xing, Jiaqi Wang, Mrinal K. Sarkar, Rachael Bogle, Tran Do, Anthony Coon, Christopher Cole, Olesya Plazyo, Joanna E. Rew, Haihan Zhang, J. Michelle Kahlenberg, Allison C. Billi, Hervé Bachelez, Lam C. Tsoi, Paul W. Harms, Shuai Shao, Xiang Chen, Jo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12859134.txt.
Description
Rundong Jiang and co-authors map the cell conversations behind a severe form of psoriasis, in a 2025 paper. Generalized pustular psoriasis fills the skin with neutrophils and can flare into a life-threatening state, yet its local immune scene was poorly charted. The team profiled sixty thousand single cells from diseased and healthy skin and added spatial mapping.
They found a neutrophil subset that lacks one control gene yet carries high levels of alarm genes, marking a shift into an attack state. These cells trade signals with skin cells that make a potent alarm protein, and a factor the neutrophils release turns the exchange up. Support cells and vessel cells act as hubs in the network, the team reports.
Catalog record
| CREATOR | Rundong Jiang, Joseph Kirma, Jennifer Fox, Xianying Xing, Jiaqi Wang, Mrinal K. Sarkar, Rachael Bogle, Tran Do, Anthony Coon, Christopher Cole, Olesya Plazyo, Joanna E. Rew, Haihan Zhang, J. Michelle Kahlenberg, Allison C. Billi, Hervé Bachelez, Lam C. Tsoi, Paul W. Harms, Shuai Shao, Xiang Chen, Jo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |