Loss of the liver circadian clock affects the expression of intrarenal renin-angiotensin system components
Soha A Hassan, Michael Stumpe, Ka Yi Hui, Marie-Nöelle Giraud, Urs Albrecht, Jürgen A Ripperger · 2025
Read Loss of the liver circadian clock affects the expression of intrarenal renin-angiotensin system components by Soha A Hassan, Michael Stumpe, Ka Yi Hui, Marie-Nöelle Giraud, Urs Albrecht, Jürgen A Ripperger (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12859090.txt.
Description
Soha Hassan, Michael Stumpe, Ka Yi Hui, and their co-authors test whether the liver's daily clock steers hormone signals inside the kidney. The kidney's own renin-angiotensin system helps hold salt and water to support blood pressure, and some of its parts rise and fall with the day.
The team used mice whose liver clocks were knocked out and measured the kidney signals across the day. Surprisingly, the daily rhythms mostly survived, though their timing shifted, which suggests the liver talks to the kidney by some other route as well. Both mouse strains did make less of a key salt-handling protein in the kidney, and their blood pressure ran lower. The work points to a backup channel between the two organs.
Catalog record
| CREATOR | Soha A Hassan, Michael Stumpe, Ka Yi Hui, Marie-Nöelle Giraud, Urs Albrecht, Jürgen A Ripperger |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |