Chromatin remodeling factor BAF155 coordinates oligodendroglial-neuronal communications linked to regional myelination and autism-like behavioral deficits in mice
Xiaorui Wang, Cong Zeng, Zhonghao Wu, Minmin Lu, Xiao Wang, Yun Xiu, Qi Wang, Shouyu Wang, Xiaoying Chen, Yan Shen, Hui Li, Yixun Su, Penghui Chen, Hui Chen, Nengyin Sheng, Wei Mo, Chenju Yi, Qingwu Yang, Alexei Verkhratsky, Jianqin Niu, Lan Xiao · 2025
Read Chromatin remodeling factor BAF155 coordinates oligodendroglial-neuronal communications linked to regional myelination and autism-like behavioral deficits in mice by Xiaorui Wang, Cong Zeng, Zhonghao Wu, Minmin Lu, Xiao Wang, Yun Xiu, Qi Wang, Shouyu Wang, Xiaoying Chen, Yan Shen, Hui Li, Yixun Su, Penghui Chen, Hui Chen, Nengyin Sheng, Wei Mo, Chenju Yi, Qingwu Yang, Alexei Verkhratsky, Jianqin Niu, Lan Xiao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12859018.txt.
Description
Xiaorui Wang and co-authors study a gene regulator that helps precursor cells talk to neurons in the mouse brain. Their 2025 study links that dialogue to myelin growth and to autism-like traits. The precursor cells are the only support cells that form direct synapse-like links with neurons.
The regulator is rich in committed precursor cells. It tunes many genes that build those links, which steers cell maturation and myelin growth. Its role varies by brain region, so myelin gaps stay local. That patchwork may mirror the varied signs seen in autism. The authors propose that faulty link-building early in life could help start the condition. Their work joins synapse genes and risk genes in one frame.
Catalog record
| CREATOR | Xiaorui Wang, Cong Zeng, Zhonghao Wu, Minmin Lu, Xiao Wang, Yun Xiu, Qi Wang, Shouyu Wang, Xiaoying Chen, Yan Shen, Hui Li, Yixun Su, Penghui Chen, Hui Chen, Nengyin Sheng, Wei Mo, Chenju Yi, Qingwu Yang, Alexei Verkhratsky, Jianqin Niu, Lan Xiao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |