Unraveling sex differences in age-related hippocampal decline: differential mitochondrial dysfunction, Lonp1-dependent mitochondrial proteostasis and mtROS production in aged C57BL/6 mice
Karina A Cicali, Claudia Jara, Daniela Cortés-Díaz, Matías Lira, Ítalo Fuentes, Alejandra Catenaccio, Josefa Arnaíz, Micaela Ricca, Sebastián Valenzuela, Carolina A Oliva, Daniela S Rivera, Cheril Tapia-Rojas · 2025
Read Unraveling sex differences in age-related hippocampal decline: differential mitochondrial dysfunction, Lonp1-dependent mitochondrial proteostasis and mtROS production in aged C57BL/6 mice by Karina A Cicali, Claudia Jara, Daniela Cortés-Díaz, Matías Lira, Ítalo Fuentes, Alejandra Catenaccio, Josefa Arnaíz, Micaela Ricca, Sebastián Valenzuela, Carolina A Oliva, Daniela S Rivera, Cheril Tapia-Rojas (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12858937.txt.
Description
The brain's sea horse zone fades with age, and the fade may take unlike paths in the two sexes. Karina Cicali and co-authors map that split in a 2025 study of old mice. They test mind skills and the health of the cells' power pods, with a guard enzyme in the frame.
Old males lost space and place marks most, while old females lost face marks. Male power pods made more harsh oxygen waste and lost charge. Female pods, by split, leaked more through a pore gate. The guard enzyme's cut force fell hard in old males, which left their pods bare. A fast age mouse line gave the same tale. Care for the fade, the team says, should be sex fit.
Catalog record
| CREATOR | Karina A Cicali, Claudia Jara, Daniela Cortés-Díaz, Matías Lira, Ítalo Fuentes, Alejandra Catenaccio, Josefa Arnaíz, Micaela Ricca, Sebastián Valenzuela, Carolina A Oliva, Daniela S Rivera, Cheril Tapia-Rojas |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 106 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |