Preventive Role of Simvastatin against Infertility: Potential Role of PGC-α/PPARβ/UCPs and NF-κβ Signaling Pathways
Ozra Motaghinejad, Mina Gholami, A. Wallace Hayes, Majid Motaghinejad, Mojgan Javedani Masroor, Arash Mohazzab · 2025
Read Preventive Role of Simvastatin against Infertility: Potential Role of PGC-α/PPARβ/UCPs and NF-κβ Signaling Pathways by Ozra Motaghinejad, Mina Gholami, A. Wallace Hayes, Majid Motaghinejad, Mojgan Javedani Masroor, Arash Mohazzab (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12857905.txt.
Description
Ozra Motaghinejad and co-authors review how a cholesterol drug might guard fertility through cell power pathways in this 2025 paper. Inflammation and oxidative stress can damage sperm and egg cells. The damage often runs through mitochondria, the cell's power plants. A broken power chain can trigger cell death in germ cells. Several signaling paths feed into that process. One path named in the title helps tune mitochondrial function.
Simvastatin, a widely used statin, is the candidate protector. The review weighs its effects on those signaling paths. A stress-response path is the second focus of the title. The authors argue the drug's anti-inflammatory action may shield fertility. The piece is a mechanism review, not a trial report. It calls for direct studies of the proposed pathways.
Catalog record
| CREATOR | Ozra Motaghinejad, Mina Gholami, A. Wallace Hayes, Majid Motaghinejad, Mojgan Javedani Masroor, Arash Mohazzab |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |