Identification and efficacy assessment of novel immunoprotective antigens from Mycoplasma synoviae for vaccine development
Luru Zhao, Weiqi Guo, Bin Zhang, Xiaochuan Tang, Yinan Liu, Jingyi Liang, Qi Wu, Yanqing Bao, Mingxing Tian, Shaohui Wang, Jingjing Qi · 2025
Read Identification and efficacy assessment of novel immunoprotective antigens from Mycoplasma synoviae for vaccine development by Luru Zhao, Weiqi Guo, Bin Zhang, Xiaochuan Tang, Yinan Liu, Jingyi Liang, Qi Wu, Yanqing Bao, Mingxing Tian, Shaohui Wang, Jingjing Qi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12855943.txt.
Description
A poultry germ that drains farm profits may yield to a new vaccine target, in a 2025 study by Luru Zhao and co-authors. Mycoplasma synoviae, listed by the world animal health body, spreads among flocks and resists cheap fixes: flock cleanup is slow, and antibiotics meet growing resistance.
The team screened the whole pangenome with reverse vaccinology, a computational hunt for proteins the immune system can see. Three candidates were chosen and tested as subunit vaccines. A foot pad challenge model scored lesions to judge protection. One protein, VY930, stood out, triggering strong antibody and cellular responses in immunized birds and beating the other candidates. The work offers a concrete candidate for a vaccine industry badly in need of one.
Catalog record
| CREATOR | Luru Zhao, Weiqi Guo, Bin Zhang, Xiaochuan Tang, Yinan Liu, Jingyi Liang, Qi Wu, Yanqing Bao, Mingxing Tian, Shaohui Wang, Jingjing Qi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |