Intracellularly coupled oscillators for synthetic biology
Gábor Holló, Jung Hun Park, Rose A Evard, Yolanda Schaerli · 2025
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Description
Gábor Holló, Jung Hun Park, Rose Evard, and Yolanda Schaerli modeled what happens when oscillators inside one cell are wired to each other, in a 2025 paper. Synthetic biology builds living systems from parts, and oscillators make handy higher-level blocks. How coupled oscillators behave inside a shared cell was still a design question.
The team sorted couplings into four grades, from independent to deeply merged, and designed circuits for each. Their models predict a wide spread of behavior: beats, swelling and shrinking waves, period doubling, chaos, resonance, and full locking in step. The point is to steer future lab work in bacteria toward the wanted regime. The authors also sketch oscillator-based computing, where the same hardware both processes and stores, with many-state and nonlinear tricks on offer.
Catalog record
| CREATOR | Gábor Holló, Jung Hun Park, Rose A Evard, Yolanda Schaerli |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |