Venetoclax resistance in preclinical KMT2A-rearranged acute lymphoblastic leukemia models is characterized by high inter- and intra-model heterogeneity
Anna Richter, Lea Kinsky, Sandra Lange, Nares Trakooljul, Frieder Hadlich, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Christian Schmidt, Michelle Busch, Tim Schreiber, Simone Kumstel, Klaus Wimmers, Hugo Murua Escobar, Christian Junghanss · 2025
Read Venetoclax resistance in preclinical KMT2A-rearranged acute lymphoblastic leukemia models is characterized by high inter- and intra-model heterogeneity by Anna Richter, Lea Kinsky, Sandra Lange, Nares Trakooljul, Frieder Hadlich, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Christian Schmidt, Michelle Busch, Tim Schreiber, Simone Kumstel, Klaus Wimmers, Hugo Murua Escobar, Christian Junghanss (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12855817.txt.
Description
Anna Richter and fourteen co-authors dissect how a targeted leukemia drug loses its grip, in this 2025 laboratory study. Venetoclax blocks BCL-2, a protein that keeps cancer cells alive, and it anchors treatment for several blood cancers. In KMT2A-rearranged acute lymphoblastic leukemia, early results look strong, yet relapse keeps coming.
The team pushed cell lines and mouse xenografts until the drug stopped working, then sequenced DNA and RNA, down to single cells. Every model responded at first, then resisted. Resistant cells carried new or known damaging variants in the guardians TP53 and BAX, but not in BCL2 itself. Expression changes varied wildly between and within models. Single-cell data implicated the tumor's neighborhood, its signaling chatter with nearby cells, in helping resistance grow.
Catalog record
| CREATOR | Anna Richter, Lea Kinsky, Sandra Lange, Nares Trakooljul, Frieder Hadlich, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Christian Schmidt, Michelle Busch, Tim Schreiber, Simone Kumstel, Klaus Wimmers, Hugo Murua Escobar, Christian Junghanss |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |