Renoprotective effects of human L-type fatty acid-binding protein (hL-FABP) in rhabdomyolysis-induced acute kidney injury
Kazuho Inoue, Seiko Hoshino, Keiichi Ohata, Takeshi Sugaya, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori · 2025
Read Renoprotective effects of human L-type fatty acid-binding protein (hL-FABP) in rhabdomyolysis-induced acute kidney injury by Kazuho Inoue, Seiko Hoshino, Keiichi Ohata, Takeshi Sugaya, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12855215.txt.
Description
Kazuho Inoue and six co-authors test a protective protein against kidney damage in mice, in a 2025 study. Crushed muscle releases proteins that can shut down the kidneys, a condition called rhabdomyolysis injury. A protein made in the kidney's tubules, L-FABP, is known to fight oxidative stress, and mice were engineered to carry the human form of it.
On the first day after injury, engineered and normal mice looked equally sick. By the third day the engineered mice recovered far better: kidney function improved, tissue damage eased, and fewer scavenger immune cells moved in. A marker of fat oxidation stopped climbing in the engineered group, and two guardian proteins rose, together blocking a form of cell death called ferroptosis. The authors credit the protein's antioxidant action.
Catalog record
| CREATOR | Kazuho Inoue, Seiko Hoshino, Keiichi Ohata, Takeshi Sugaya, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |