The impact of type 1 diabetes mellitus on intellectual status: A Mendelian randomization study
Rong Bao, Zhangyan Shi, Hanteng Wang, Puyan Zhu, Bingyu Zhang, Haixiang Zhang, Kejin Zhang · 2025
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Description
Rong Bao and co-authors use genetic evidence to test whether type 1 diabetes itself lowers intelligence. Their 2025 study applies Mendelian randomization, which treats inherited variants as a natural experiment, free of many confounders. Whether the disease harms thinking, or merely travels with other risks, had stayed uncertain.
The analysis found a causal link from the disease to lower intelligence scores and a raised risk of intellectual disability. Several extended methods, built to catch hidden bias, agreed with the main result. Genetic signals also tied the disease to slower structural brain growth, including smaller key memory regions. The authors say the evidence is robust that the disease itself plays a role. They call for work on mechanisms, since protecting cognition could improve patients' daily treatment and life quality.
Catalog record
| CREATOR | Rong Bao, Zhangyan Shi, Hanteng Wang, Puyan Zhu, Bingyu Zhang, Haixiang Zhang, Kejin Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |