Integrative single-cell and spatial transcriptomic analysis reveals lipid metabolism–mediated macrophage heterogeneity during colorectal cancer liver metastasis progression
Xin Qi, Siyu Hou, Shaozhuo Xie, Jiajia Chen · 2025
Read Integrative single-cell and spatial transcriptomic analysis reveals lipid metabolism–mediated macrophage heterogeneity during colorectal cancer liver metastasis progression by Xin Qi, Siyu Hou, Shaozhuo Xie, Jiajia Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12853981.txt.
Description
Xin Qi and co-authors map how fat handling shapes immune cells inside bowel cancer that has spread to the liver, in a 2025 study. Liver spread is the main killer in colorectal cancer, and the tumour's surroundings steer its course. Macrophages, the immune system's scavenger cells, behave very differently depending on their fat metabolism, but the details were unclear. The team combined two gene-reading methods to compare healthy colon, primary tumours, and liver deposits.
One method read single cells; the other preserved where cells sat in the tissue. Macrophages showed the strongest fat-processing activity of any cell type. The analysis traced their development paths, their chatter with neighbours, and their positions. The picture links greasy metabolism to the states that help metastases grow, suggesting new drug targets among the fat-handling machinery.
Catalog record
| CREATOR | Xin Qi, Siyu Hou, Shaozhuo Xie, Jiajia Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |