Targeted protein degradation: species, diseases and efficient utilization
Tian Yue, Jian He, Jun Hou · 2025
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Description
Tian Yue, Jian He, and Jun Hou review in 2025 targeted protein degradation, a drug strategy that removes disease proteins instead of just blocking them. The cell's own disposal routes, the proteasome and the lysosome, do the clearing once a drug tags the target. Cancer leads the field, with hormone and cycle proteins as prized quarry.
Brain wasting and immune diseases follow close behind. Weak uptake and off target hits still hamper real use, the authors note. Delivery systems that ferry the drugs may lift both faults. The review maps species, diseases, and smarter use of the approach.
Catalog record
| CREATOR | Tian Yue, Jian He, Jun Hou |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |