Conditioned media and extracellular vesicles derived from human Wharton’s jelly mesenchymal stem cells improve the in vitro maturation of immature oocytes in normal and PCOS mouse model
Arezoo Solati, Sanaz Alaee, Fatemeh Zal, Zahra Khodabandeh, Mahintaj Dara, Shayesteh Mehdinejadiani, Sedigheh Bahmyari · 2025
Read Conditioned media and extracellular vesicles derived from human Wharton’s jelly mesenchymal stem cells improve the in vitro maturation of immature oocytes in normal and PCOS mouse model by Arezoo Solati, Sanaz Alaee, Fatemeh Zal, Zahra Khodabandeh, Mahintaj Dara, Shayesteh Mehdinejadiani, Sedigheh Bahmyari (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12853761.txt.
Description
Arezoo Solati and six co-authors test stem-cell products for maturing eggs in a 2025 paper. They used fluid the cells grew in, and the tiny vesicles those cells shed, both from umbilical cord tissue stem cells. Immature eggs came from normal mice and from mice given a drug-induced version of a common hormone disorder. Eggs were matured in dishes with plain medium or medium plus one of the products. Staining picked out promising eggs first.
Both products raised maturation rates compared with plain medium. Eggs from disorder-model mice matured poorly and degenerated more, but treatment rescued much of that loss. Gene activity shifts in key cell-cycle regulators matched the improvement.
Catalog record
| CREATOR | Arezoo Solati, Sanaz Alaee, Fatemeh Zal, Zahra Khodabandeh, Mahintaj Dara, Shayesteh Mehdinejadiani, Sedigheh Bahmyari |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |