A perfusable decellularized plant-based air-liquid-interface-on-a-chip for investigating inorganic dust aerosol exposure
Omur Sert, Tolga Erdogan, Yagmur Arslan, Ozlem Yesil-Celiktas · 2025
Read A perfusable decellularized plant-based air-liquid-interface-on-a-chip for investigating inorganic dust aerosol exposure by Omur Sert, Tolga Erdogan, Yagmur Arslan, Ozlem Yesil-Celiktas (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12852814.txt.
Description
Omur Sert and co-authors describe, in a 2025 study, a lab chip that mimics the airway surface using a cleaned plant scaffold. Dust harms hundreds of millions of people and can reach deep into the lungs, yet lab models lack a working airway-to-blood vessel surface. The team used plant vessels as a natural network for that surface.
Cleaning removed nearly all plant DNA while keeping the vessel web and a water-loving surface. Human airway and vessel cells then grew on the scaffold inside a small flow device. Fine dust lowered the barrier strength sharply and raised swelling signals in the cells. The chip offers a plant-based way to study inhaled dust harm.
Catalog record
| CREATOR | Omur Sert, Tolga Erdogan, Yagmur Arslan, Ozlem Yesil-Celiktas |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |