hECA v2.0: an AI-ready ensemble cell atlas of single-cell RNA and ATAC sequencing data

Xi Xi, Yixin Chen, Xinze Wu, Minsheng Hao, Jiaqi Li, Haiyang Bian, Qiuchen Meng, Fanhong Li, Chen Li, Chuxi Xiao, Xiaomin Dong, Renke You, Yifan Xiong, Peng Yang, Zijing Gao, Xuejian Cui, Yan Pan, Zhen Li, Wenrui Li, Zhuofeng Li, Xiaoyang Chen, Yanfei Cui, Hairong Lv, Rui Jiang, Lei Wei, Xuegong Zha · 2025

Read hECA v2.0: an AI-ready ensemble cell atlas of single-cell RNA and ATAC sequencing data by Xi Xi, Yixin Chen, Xinze Wu, Minsheng Hao, Jiaqi Li, Haiyang Bian, Qiuchen Meng, Fanhong Li, Chen Li, Chuxi Xiao, Xiaomin Dong, Renke You, Yifan Xiong, Peng Yang, Zijing Gao, Xuejian Cui, Yan Pan, Zhen Li, Wenrui Li, Zhuofeng Li, Xiaoyang Chen, Yanfei Cui, Hairong Lv, Rui Jiang, Lei Wei, Xuegong Zha (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12852668.txt.

Description

Xi Xi and co-authors release a second, AI-ready edition of a human cell atlas in a 2025 paper. Single-cell data pile up in scattered sets that models cannot easily learn from. The atlas now unites gene activity reads from over ten million cells with openness-of-DNA reads from well over a million more.

Forty-two organs and tissues are covered under one label scheme, with cell types rechecked by hand for consistency. A large cell model was pre-trained on the set to prove its worth. The resource aims to be the training ground for the next wave of cell AI.

Catalog record

CREATORXi Xi, Yixin Chen, Xinze Wu, Minsheng Hao, Jiaqi Li, Haiyang Bian, Qiuchen Meng, Fanhong Li, Chen Li, Chuxi Xiao, Xiaomin Dong, Renke You, Yifan Xiong, Peng Yang, Zijing Gao, Xuejian Cui, Yan Pan, Zhen Li, Wenrui Li, Zhuofeng Li, Xiaoyang Chen, Yanfei Cui, Hairong Lv, Rui Jiang, Lei Wei, Xuegong Zha
YEAR2025
COLLECTIONPAPERS
FORMATTXT
FILE SIZE33 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC12852668

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