Unambiguous analytical separation and improved syntheses of [11C]acetate and [11C]acetoacetate
Karsten Bamminger, Lukas Nics, Marcus Hacker, Cécile Philippe, Marius Ozenil · 2025
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Description
Karsten Bamminger and four co-authors improved how two short-lived tracers for body scans are made and checked. The tracers tag acetate and a ketone body with a hot form of carbon. Scans with them read how tissue burns fuel and uses ketones. The catch is that the two tracers look much alike, so a lax check can mix them up.
Both were made on a standard lab rig, with pure yields the team calls high. A tweak to the gas step lifted the trapped share of hot carbon from about six in ten to near nine in ten. The old check method could not tell the two tracers apart at all. A new method split them cleanly. The pair warn that most past work on the ketone tracer likely missed acetate as a flaw in the mix.
Catalog record
| CREATOR | Karsten Bamminger, Lukas Nics, Marcus Hacker, Cécile Philippe, Marius Ozenil |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |