Transcriptomic decoding of regional cortical vulnerability to drug-resistant epilepsy using 7T MRI
Haixia Mao, Teppei Matsubara, Naoaki Tanaka, Noam Peled, Hana Farzaneh, Diana Melania lon, Nao Suzuki, Robert Mark Richardson, Andrew J. Cole, Xiangming Fang, Steven M. Stufflebeam · 2025
Read Transcriptomic decoding of regional cortical vulnerability to drug-resistant epilepsy using 7T MRI by Haixia Mao, Teppei Matsubara, Naoaki Tanaka, Noam Peled, Hana Farzaneh, Diana Melania lon, Nao Suzuki, Robert Mark Richardson, Andrew J. Cole, Xiangming Fang, Steven M. Stufflebeam (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12852118.txt.
Description
Haixia Mao and co-authors present a 2025 study linking brain scans and gene activity in drug-resistant epilepsy. Why some cortical regions succumb while others resist is unknown. The team scanned 105 patients and 105 healthy controls with a powerful 7-tesla MRI, measuring local activity strength and synchrony.
Patients showed weaker activity amplitude but stronger local synchrony, chiefly in a control network spanning the cingulate and operculum. Matching those maps against a human brain gene atlas pointed to epilepsy-linked genes and brain genes more broadly. Genes tracking the activity changes clustered in energy production inside mitochondria, acid metabolism, and the machinery that packages DNA and builds synapses. The work ties regional weakness to concrete molecular programs.
Catalog record
| CREATOR | Haixia Mao, Teppei Matsubara, Naoaki Tanaka, Noam Peled, Hana Farzaneh, Diana Melania lon, Nao Suzuki, Robert Mark Richardson, Andrew J. Cole, Xiangming Fang, Steven M. Stufflebeam |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |