Serum response factor targets Cyr61 to facilitate chronic progression after ischemic acute kidney injury through renal tubular epithelial–myofibroblast transdifferentiation
Lin Che, Lingyu Xu, Chenyu Li, Chen Guan, Quandong Bu, Congjuan Luo, Hong Luan, Bin Zhou, Chengyu Yang, Xiaofei Man, Hui Zhang, Yan Xu, Long Zhao · 2025
Read Serum response factor targets Cyr61 to facilitate chronic progression after ischemic acute kidney injury through renal tubular epithelial–myofibroblast transdifferentiation by Lin Che, Lingyu Xu, Chenyu Li, Chen Guan, Quandong Bu, Congjuan Luo, Hong Luan, Bin Zhou, Chengyu Yang, Xiaofei Man, Hui Zhang, Yan Xu, Long Zhao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12849740.txt.
Description
Che and a team of colleagues traced a signaling chain that turns kidney tubule cells into scar-forming cells in twenty twenty-five. After a kidney loses blood flow, some tubule cells change identity, a process called transdifferentiation, and drive long-term scarring. The chain centers on a gene switch, SRF, and its target gene Cyr61.
In mouse kidney cells starved of oxygen and in rat kidney tissue after blocked blood flow, SRF and Cyr61 rose together with scar markers, while normal tubule markers fell. Forcing SRF higher raised Cyr61 further. Blocking SRF with a drug or silencing its gene cut Cyr61, protected tubule cells from changing identity, and eased chronic damage in cells and animals. The authors propose the SRF blocker as a treatment candidate.
Catalog record
| CREATOR | Lin Che, Lingyu Xu, Chenyu Li, Chen Guan, Quandong Bu, Congjuan Luo, Hong Luan, Bin Zhou, Chengyu Yang, Xiaofei Man, Hui Zhang, Yan Xu, Long Zhao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |